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CK1d in complex with {4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDIN-2-YL}METHANOL inhibitor

X-ray diffraction
1.98Å resolution
PDB entry 4kbc coloured by chain, front view.
PDB entry 4kbc coloured by chain, side view.
PDB entry 4kbc coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Casein kinase I isoform delta
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Multimeric state: monomeric
Accessible surface area: 14460.34 Å2
Buried surface area: 565.08 Å2
Dissociation area: 86.07 Å2
Dissociation energy (ΔGdiss): -1.7 kcal/mol
Dissociation entropy (TΔSdiss): 0.04 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155796
Assembly 2
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Assembly Name: Casein kinase I isoform delta
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Multimeric state: monomeric
Accessible surface area: 13950.99 Å2
Buried surface area: 1122.75 Å2
Dissociation area: 80.78 Å2
Dissociation energy (ΔGdiss): 10.08 kcal/mol
Dissociation entropy (TΔSdiss): 0.57 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155796
Assembly 3
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Assembly Name: Casein kinase I isoform delta
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Multimeric state: homo dimer
Accessible surface area: 26741.4 Å2
Buried surface area: 3357.76 Å2
Dissociation area: 894.94 Å2
Dissociation energy (ΔGdiss): 0.81 kcal/mol
Dissociation entropy (TΔSdiss): 13.07 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-546142
Assembly 4
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Assembly Name: Casein kinase I isoform delta
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Multimeric state: homo dimer
Accessible surface area: 25839.87 Å2
Buried surface area: 4259.3 Å2
Dissociation area: 1,285.73 Å2
Dissociation energy (ΔGdiss): 1.89 kcal/mol
Dissociation entropy (TΔSdiss): 13.58 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-546142

Macromolecules

Casein kinase I isoform delta
Chains: A, B
Length: 317 amino acids
Theoretical weight: 37 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P48730 (Residues: 1-317; Coverage: 76%)
Gene names: CSNK1D, HCKID
Pfam: Protein kinase domain
InterPro:
CATH:
Casein kinase I isoform delta in PDB entry 4kbc, assembly 1, front view.
Casein kinase I isoform delta in PDB entry 4kbc, assembly 1, side view.
Casein kinase I isoform delta in PDB entry 4kbc, assembly 1, top view.
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