Function and Biology

Crystal structure of NpuDnaE intein

Source organism: Nostoc punctiforme PCC 73102
Biochemical function: not assigned
Biological process: intein-mediated protein splicing
Cellular component: not assigned

EC 2.7.7.7: DNA-directed DNA polymerase

Reaction catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Systematic name:
Deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
Alternative Name(s):
  • DNA duplicase
  • DNA nucleotidyltransferase
  • DNA nucleotidyltransferase (DNA-directed)
  • DNA polymerase
  • DNA polymerase I
  • DNA polymerase II
  • DNA polymerase III
  • DNA polymerase alpha
  • DNA polymerase beta
  • DNA polymerase gamma
  • DNA replicase
  • DNA-dependent DNA polymerase
  • Deoxynucleate polymerase
  • Deoxyribonucleate nucleotidyltransferase
  • Deoxyribonucleic acid duplicase
  • Deoxyribonucleic acid polymerase
  • Deoxyribonucleic duplicase
  • Deoxyribonucleic polymerase
  • Deoxyribonucleic polymerase I
  • Duplicase
  • Klenow fragment
  • Sequenase
  • Taq DNA polymerase
  • Taq Pol I
  • Tca DNA polymerase

GO terms

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Sequence family

InterPro InterPro annotations
IPR006141
Domain description: Intein N-terminal splicing region
Occurring in:
  1. DNA polymerase III, alpha subunit; Nucleic acid binding, OB-fold, tRNA/helicase-type
IPR030934
Domain description: Intein C-terminal splicing region
Occurring in:
  1. DNA polymerase III, alpha subunit; Nucleic acid binding, OB-fold, tRNA/helicase-type
IPR036844
Domain description: Hint domain superfamily
Occurring in:
  1. DNA polymerase III, alpha subunit; Nucleic acid binding, OB-fold, tRNA/helicase-type
IPR003587
Domain description: Hint domain N-terminal
Occurring in:
  1. DNA polymerase III, alpha subunit; Nucleic acid binding, OB-fold, tRNA/helicase-type

Structure domain

CATH CATH domain
2.170.16.10
Class: Mainly Beta
Architecture: Beta Complex
Topology: Endonuclease - Pi-scei; Chain A, domain 1
Homology: Hedgehog/Intein (Hint) domain
Occurring in:
  1. DNA polymerase III, alpha subunit; Nucleic acid binding, OB-fold, tRNA/helicase-type
The deposited structure of PDB entry 4kl5 contains 2 copies of CATH domain 2.170.16.10 (Endonuclease - Pi-scei; Chain A, domain 1) in DNA-directed DNA polymerase. Showing 1 copy in chain B.