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Probing the N-terminal beta-sheet conversion in the crystal structure of the full-length human prion protein bound to a Nanobody

X-ray diffraction
1.5Å resolution
PDB entry 4kml coloured by chain, front view.
PDB entry 4kml coloured by chain, side view.
PDB entry 4kml coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Major prion protein and IG-heavy chain
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Multimeric state: hetero dimer
Accessible surface area: 11531.39 Å2
Buried surface area: 1257.48 Å2
Dissociation area: 628.74 Å2
Dissociation energy (ΔGdiss): -2.85 kcal/mol
Dissociation entropy (TΔSdiss): 10.91 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-208987

Macromolecules

Major prion protein
Chain: A
Length: 241 amino acids
Theoretical weight: 26.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04156 (Residues: 24-231; Coverage: 90%)
Gene names: ALTPRP, PRIP, PRNP, PRP
Pfam: Prion/Doppel alpha-helical domain
InterPro:
Major prion protein in PDB entry 4kml, assembly 1, front view.
Major prion protein in PDB entry 4kml, assembly 1, side view.
Major prion protein in PDB entry 4kml, assembly 1, top view.
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Nanobody
Chain: B
Length: 130 amino acids
Theoretical weight: 14.28 KDa
Source organism: Lama glama
Expression system: Escherichia coli
InterPro:
CATH: Immunoglobulins
Nanobody in PDB entry 4kml, assembly 1, front view.
Nanobody in PDB entry 4kml, assembly 1, side view.
Nanobody in PDB entry 4kml, assembly 1, top view.
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