Structure analysis

Crystal Structure Analysis of human IDH1 mutants in complex with NADP+ and Ca2+/alpha-Ketoglutarate

X-ray diffraction
2.204Å resolution
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 30658.27 Å2
Buried surface area: 11194.41 Å2
Dissociation area: 4,076.53 Å2
Dissociation energy (ΔGdiss): 61.23 kcal/mol
Dissociation entropy (TΔSdiss): 15.14 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-131150
Assembly 2
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Multimeric state: homo dimer
Accessible surface area: 29888.97 Å2
Buried surface area: 11263.5 Å2
Dissociation area: 4,191.92 Å2
Dissociation energy (ΔGdiss): 58.13 kcal/mol
Dissociation entropy (TΔSdiss): 15.16 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-131150

Macromolecules

Chains: A, B, C
Length: 425 amino acids
Theoretical weight: 48.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75874 (Residues: 1-414; Coverage: 100%)
Gene names: IDH1, PICD
Pfam: Isocitrate/isopropylmalate dehydrogenase
InterPro:
CATH: Isopropylmalate Dehydrogenase

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