Structure analysis

Structure of mouse cGAS bound to 18 bp DNA

X-ray diffraction
2.5Å resolution
Source organism: Mus musculus
Assembly composition:
hetero hexamer (preferred)
Entry contents: 1 distinct polypeptide molecule
1 distinct DNA molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero hexamer
Accessible surface area: 43617.97 Å2
Buried surface area: 9761.15 Å2
Dissociation area: 1,719.69 Å2
Dissociation energy (ΔGdiss): 0.24 kcal/mol
Dissociation entropy (TΔSdiss): 14.43 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-117785
Assembly 2
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Multimeric state: hetero hexamer
Accessible surface area: 43322.29 Å2
Buried surface area: 9759.0 Å2
Dissociation area: 1,736.48 Å2
Dissociation energy (ΔGdiss): 3.34 kcal/mol
Dissociation entropy (TΔSdiss): 14.43 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-117785

Macromolecules

Chains: A, B, C, D
Length: 366 amino acids
Theoretical weight: 42.98 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8C6L5 (Residues: 142-507; Coverage: 72%)
Gene names: Cgas, Mb21d1
Pfam:
InterPro:
CATH:

Search similar proteins

Name: 18 bp dsDNA
Representative chains: E, F, G, H, I, J, K, L
Source organism: Mus musculus [10090]
Expression system: Not provided
Length: 18 nucleotides
Theoretical weight: 5.51 KDa

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