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Structure of wild-type HIV protease in complex with darunavir

Source organism: Human immunodeficiency virus 1
Biochemical function: aspartic-type endopeptidase activity
Biological process: proteolysis
Cellular component: not assigned

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GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00077
Domain description: Retroviral aspartyl protease
Occurring in:
  1. Protease
The deposited structure of PDB entry 4ll3 contains 2 copies of Pfam domain PF00077 (Retroviral aspartyl protease) in Protease. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR021109
Domain description: Aspartic peptidase domain superfamily
Occurring in:
  1. Protease
IPR001969
Domain description: Aspartic peptidase, active site
Occurring in:
  1. Protease
IPR001995
Domain description: Peptidase A2A, retrovirus, catalytic
Occurring in:
  1. Protease
IPR034170
Domain description: Retropepsin-like catalytic domain
Occurring in:
  1. Protease
IPR018061
Domain description: Retropepsins
Occurring in:
  1. Protease

Structure domain

CATH CATH domain
2.40.70.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Cathepsin D, subunit A; domain 1
Homology: Acid Proteases
Occurring in:
  1. Protease
The deposited structure of PDB entry 4ll3 contains 2 copies of CATH domain 2.40.70.10 (Cathepsin D, subunit A; domain 1) in Protease. Showing 1 copy in chain A.

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