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Structure of the eag domain-CNBHD complex of the mouse EAG1 channel

X-ray diffraction
1.995Å resolution
PDB entry 4llo coloured by chain, front view.
PDB entry 4llo coloured by chain, side view.
PDB entry 4llo coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Potassium voltage-gated channel subfamily H member 1
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Multimeric state: hetero dimer
Accessible surface area: 14606.81 Å2
Buried surface area: 1422.44 Å2
Dissociation area: 711.22 Å2
Dissociation energy (ΔGdiss): 2.25 kcal/mol
Dissociation entropy (TΔSdiss): 11.45 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-178793
Assembly 2
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Assembly Name: Potassium voltage-gated channel subfamily H member 1
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Multimeric state: hetero dimer
Accessible surface area: 13845.7 Å2
Buried surface area: 1269.46 Å2
Dissociation area: 634.73 Å2
Dissociation energy (ΔGdiss): 1.21 kcal/mol
Dissociation entropy (TΔSdiss): 11.24 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-178793
Assembly 3
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Assembly Name: Potassium voltage-gated channel subfamily H member 1
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Multimeric state: hetero dimer
Accessible surface area: 14564.97 Å2
Buried surface area: 1582.8 Å2
Dissociation area: 791.4 Å2
Dissociation energy (ΔGdiss): 1.86 kcal/mol
Dissociation entropy (TΔSdiss): 11.5 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-178793
Assembly 4
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Assembly Name: Potassium voltage-gated channel subfamily H member 1
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Multimeric state: hetero dimer
Accessible surface area: 13821.15 Å2
Buried surface area: 1280.43 Å2
Dissociation area: 640.21 Å2
Dissociation energy (ΔGdiss): 1.23 kcal/mol
Dissociation entropy (TΔSdiss): 11.25 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-178793

Macromolecules

Voltage-gated delayed rectifier potassium channel KCNH1
Chains: A, C, E, G
Length: 177 amino acids
Theoretical weight: 20.13 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q60603 (Residues: 552-724; Coverage: 18%)
Gene names: Eag1, Kcnh1
Pfam: Cyclic nucleotide-binding domain
InterPro:
CATH: Jelly Rolls
Potassium voltage-gated channel subfamily H member 1 in PDB entry 4llo, assembly 1, front view.
Potassium voltage-gated channel subfamily H member 1 in PDB entry 4llo, assembly 1, side view.
Potassium voltage-gated channel subfamily H member 1 in PDB entry 4llo, assembly 1, top view.
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Voltage-gated delayed rectifier potassium channel KCNH1
Chains: B, D, F, H
Length: 134 amino acids
Theoretical weight: 15.52 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q60603 (Residues: 6-136; Coverage: 13%)
Gene names: Eag1, Kcnh1
Pfam: PAS domain
InterPro:
CATH: PAS domain
Potassium voltage-gated channel subfamily H member 1 in PDB entry 4llo, assembly 1, front view.
Potassium voltage-gated channel subfamily H member 1 in PDB entry 4llo, assembly 1, side view.
Potassium voltage-gated channel subfamily H member 1 in PDB entry 4llo, assembly 1, top view.
Molecule details ›

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