Function and Biology

crystal structure of RpiA-R5P complex

Source organism: Francisella tularensis
Biochemical function: isomerase activity
Biological process: small molecule metabolic process
Cellular component: cytosol

EC 5.3.1.6: Ribose-5-phosphate isomerase

Reaction catalysed:
D-ribose 5-phosphate = D-ribulose 5-phosphate
Systematic name:
D-ribose-5-phosphate aldose-ketose-isomerase
Alternative Name(s):
  • 5-phosphoribose isomerase
  • D-ribose 5-phosphate isomerase
  • D-ribose-5-phosphate ketol-isomerase
  • Phosphopentoseisomerase
  • Phosphopentosisomerase
  • Phosphoriboisomerase
  • Ribose 5-phosphate epimerase
  • Ribose phosphate isomerase

Sequence family

Pfam Protein family (Pfam)
PF06026
Domain description: Ribose 5-phosphate isomerase A (phosphoriboisomerase A)
Occurring in:
  1. Ribose-5-phosphate isomerase A
The deposited structure of PDB entry 4m8l contains 4 copies of Pfam domain PF06026 (Ribose 5-phosphate isomerase A (phosphoriboisomerase A)) in Ribose-5-phosphate isomerase A. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR004788
Domain description: Ribose 5-phosphate isomerase, type A
Occurring in:
  1. Ribose-5-phosphate isomerase A
IPR020672
Domain description: Ribose-5-phosphate isomerase, type A, subgroup
Occurring in:
  1. Ribose-5-phosphate isomerase A
IPR037171
Domain description: NagB/RpiA transferase-like
Occurring in:
  1. Ribose-5-phosphate isomerase A

Structure domains

CATH CATH domains
3.40.50.1360
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Ribose-5-phosphate isomerase A
The deposited structure of PDB entry 4m8l contains 4 copies of CATH domain 3.40.50.1360 (Rossmann fold) in Ribose-5-phosphate isomerase A. Showing 1 copy in chain A.
3.30.70.260
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Alpha-Beta Plaits
Occurring in:
  1. Ribose-5-phosphate isomerase A
The deposited structure of PDB entry 4m8l contains 4 copies of CATH domain 3.30.70.260 (Alpha-Beta Plaits) in Ribose-5-phosphate isomerase A. Showing 1 copy in chain A.