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Structure of a novel submicromolar MDM2 inhibitor

X-ray diffraction
2.119Å resolution
PDB entry 4mdq coloured by chain, front view.
PDB entry 4mdq coloured by chain, side view.
PDB entry 4mdq coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: E3 ubiquitin-protein ligase Mdm2
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Multimeric state: monomeric
Accessible surface area: 5568.17 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169499

Macromolecules

E3 ubiquitin-protein ligase Mdm2
Chain: A
Length: 86 amino acids
Theoretical weight: 10.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q00987 (Residues: 25-110; Coverage: 18%)
Gene name: MDM2
Pfam: SWIB/MDM2 domain
InterPro:
CATH: SWIB/MDM2 domain
E3 ubiquitin-protein ligase Mdm2 in PDB entry 4mdq, assembly 1, front view.
E3 ubiquitin-protein ligase Mdm2 in PDB entry 4mdq, assembly 1, side view.
E3 ubiquitin-protein ligase Mdm2 in PDB entry 4mdq, assembly 1, top view.
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