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Carbonmonoxy Structure of the Human Fetal Hemoglobin Mutant HbF Toms River alphawtgammaV67M

X-ray diffraction
2.242Å resolution
PDB entry 4mqk coloured by chain, front view.
PDB entry 4mqk coloured by chain, side view.
PDB entry 4mqk coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Hemoglobin HbF Variant 2 complex
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Multimeric state: hetero tetramer
Accessible surface area: 23438.97 Å2
Buried surface area: 11824.5 Å2
Dissociation area: 3,303.55 Å2
Dissociation energy (ΔGdiss): 4.61 kcal/mol
Dissociation entropy (TΔSdiss): 36.7 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-159679
Complex Portal ID: CPX-2933
Assembly 2
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Assembly Name: Hemoglobin HbF Variant 2 complex
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Multimeric state: hetero tetramer
Accessible surface area: 23245.93 Å2
Buried surface area: 11839.55 Å2
Dissociation area: 3,326.94 Å2
Dissociation energy (ΔGdiss): 8.17 kcal/mol
Dissociation entropy (TΔSdiss): 36.72 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-159679
Complex Portal ID: CPX-2933

Macromolecules

Hemoglobin subunit alpha
Chains: A, C, E, G
Length: 141 amino acids
Theoretical weight: 15.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P69905 (Residues: 2-142; Coverage: 99%)
Gene names: HBA1, HBA2
Pfam: Globin
InterPro:
CATH: Globins
Hemoglobin subunit alpha in PDB entry 4mqk, assembly 1, front view.
Hemoglobin subunit alpha in PDB entry 4mqk, assembly 1, side view.
Hemoglobin subunit alpha in PDB entry 4mqk, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P69905  
1141102030405060708090100110120130140
 
50100
UniProt
P69905
PRO_0000455882
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
Interaction interfaces
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Hemoglobin subunit gamma-2
Chains: B, D, F, H
Length: 146 amino acids
Theoretical weight: 16.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P69892 (Residues: 2-147; Coverage: 99%)
Gene name: HBG2
Pfam: Globin
InterPro:
CATH: Globins
Hemoglobin subunit gamma-2 in PDB entry 4mqk, assembly 1, front view.
Hemoglobin subunit gamma-2 in PDB entry 4mqk, assembly 1, side view.
Hemoglobin subunit gamma-2 in PDB entry 4mqk, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P69892  
114620406080100120140
 
50100
UniProt
P69892
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
Interaction interfaces
Molecule details ›

Search similar proteins

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