› 4mr0

X-ray diffraction
1.95Å resolution

Crystal structure of PfbA, a surface adhesin of Streptococcus pneumoniae

Released:
DOI: 10.2210/pdb4mr0/pdb
Model geometry
Fit model/data
PDB entry 4mr0 coloured by chain, front view.
PDB entry 4mr0 coloured by chain, side view.
PDB entry 4mr0 coloured by chain, top view.
Source organism: Streptococcus pneumoniae R6
Primary publication:
Crystal structure of PfbA, a surface adhesin of Streptococcus pneumoniae, provides hints into its interaction with fibronectin.
Beulin DS, Yamaguchi M, Kawabata S, Ponnuraj K
Int J Biol Macromol 64 168-73 (2014)
PMID: 24321492

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184022 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plasmin and fibronectin-binding protein A Chains: A, B
Molecule details ›
Chains: A, B
Length: 648 amino acids
Theoretical weight: 71.36 KDa
Source organism: Streptococcus pneumoniae R6
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8CYC9 (Residues: 150-607; Coverage: 68%)
Gene names: pfbA, spr1652
Sequence domains:
Structure domains: Single-stranded right-handed beta-helix, Pectin lyase-like

Ligands and Environments

4 bound ligands:
Ligand BME 2 x BME
Ligand CA 2 x CA
Ligand CL 2 x CL
Ligand MN 8 x MN
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: P21
Unit cell:
a: 60.59Å b: 126.08Å c: 63.48Å
α: 90° β: 99.6° γ: 90°
R-values:
R R work R free
0.22 0.204 0.222
Expression system: Escherichia coli

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Citations

2 review citations

Review: current and new generation pneumococcal vaccines.
Feldman et al. (2014)
1 more