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Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and BPAM-344 at 1.87 A resolution

Source organism: Rattus norvegicus
Biochemical function: ligand-gated monoatomic ion channel activity
Biological process: not assigned
Cellular component: membrane

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GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00060
Domain description: Ligand-gated ion channel
Occurring in:
  1. Glutamate receptor 2

PF10613
Domain description: Ligated ion channel L-glutamate- and glycine-binding site
Occurring in:
  1. Glutamate receptor 2
The deposited structure of PDB entry 4n07 contains 3 copies of Pfam domain PF10613 (Ligated ion channel L-glutamate- and glycine-binding site) in Glutamate receptor 2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR019594
Domain description: Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
Occurring in:
  1. Glutamate receptor 2
IPR015683
Domain description: Ionotropic glutamate receptor
Occurring in:
  1. Glutamate receptor 2
IPR001638
Domain description: Solute-binding protein family 3/N-terminal domain of MltF
Occurring in:
  1. Glutamate receptor 2
IPR001320
Domain description: Ionotropic glutamate receptor, C-terminal
Occurring in:
  1. Glutamate receptor 2

Structure domain

CATH CATH domain
3.40.190.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: D-Maltodextrin-Binding Protein; domain 2
Homology: Periplasmic binding protein-like II
Occurring in:
  1. Glutamate receptor 2
The deposited structure of PDB entry 4n07 contains 6 copies of CATH domain 3.40.190.10 (D-Maltodextrin-Binding Protein; domain 2) in Glutamate receptor 2. Showing 2 copies in chain A.

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