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Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and BPAM-344 at 1.87 A resolution

X-ray diffraction
1.87Å resolution
PDB entry 4n07 coloured by chain, front view.
PDB entry 4n07 coloured by chain, side view.
PDB entry 4n07 coloured by chain, top view.
Source organism: Rattus norvegicus
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Glutamate receptor 2
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Multimeric state: homo dimer
Accessible surface area: 23112.42 Å2
Buried surface area: 7646.03 Å2
Dissociation area: 1,181.44 Å2
Dissociation energy (ΔGdiss): 1.01 kcal/mol
Dissociation entropy (TΔSdiss): 13.4 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-148607
Assembly 2
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Assembly Name: Glutamate receptor 2
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Multimeric state: homo dimer
Accessible surface area: 22987.19 Å2
Buried surface area: 4673.53 Å2
Dissociation area: 1,346.6 Å2
Dissociation energy (ΔGdiss): 2.11 kcal/mol
Dissociation entropy (TΔSdiss): 13.39 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-148607

Macromolecules

Glutamate receptor 2
Chains: A, B, C
Length: 263 amino acids
Theoretical weight: 29.24 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P19491 (Residues: 413-527, 653-796; Coverage: 30%)
Gene names: GluA2, Glur2, Gria2
Pfam:
InterPro:
CATH: Periplasmic binding protein-like II
Glutamate receptor 2 in PDB entry 4n07, assembly 1, front view.
Glutamate receptor 2 in PDB entry 4n07, assembly 1, side view.
Glutamate receptor 2 in PDB entry 4n07, assembly 1, top view.
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