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Human sialidase 2 in complex with 2,3-difluorosialic acid (covalent intermediate)

X-ray diffraction
2.513Å resolution
PDB entry 4nc5 coloured by chain, front view.
PDB entry 4nc5 coloured by chain, side view.
PDB entry 4nc5 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Sialidase-2
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Multimeric state: monomeric
Accessible surface area: 14672.73 Å2
Buried surface area: 889.7 Å2
Dissociation area: 263.19 Å2
Dissociation energy (ΔGdiss): -0.01 kcal/mol
Dissociation entropy (TΔSdiss): 4.03 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-195217

Macromolecules

Sialidase-2
Chain: A
Length: 382 amino acids
Theoretical weight: 42.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y3R4 (Residues: 1-380; Coverage: 100%)
Gene name: NEU2
Pfam: BNR repeat-like domain
InterPro:
CATH: Neuraminidase
Sialidase-2 in PDB entry 4nc5, assembly 1, front view.
Sialidase-2 in PDB entry 4nc5, assembly 1, side view.
Sialidase-2 in PDB entry 4nc5, assembly 1, top view.
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