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The crystal structure of tryptophan synthase subunit beta from Bacillus anthracis str. 'Ames Ancestor'

Source organism: Bacillus anthracis str. 'Ames Ancestor'
Biochemical function: lyase activity
Biological process: tryptophan metabolic process
Cellular component: cytoplasm

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EC 4.2.1.20: Tryptophan synthase

Reaction catalysed:
(1a) 1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate
Systematic name:
L-serine hydro-lyase (adding 1-C-(indol-3-yl)glycerol 3-phosphate; L-tryptophan and glyceraldehyde-3-phosphate-forming)
Alternative Name(s):
  • Indoleglycerol phosphate aldolase
  • L-serine hydro-lyase (adding indoleglycerol-phosphate)
  • L-tryptophan synthetase
  • Tryptophan desmolase
  • Tryptophan synthetase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00291
Domain description: Pyridoxal-phosphate dependent enzyme
Occurring in:
  1. Tryptophan synthase beta chain
The deposited structure of PDB entry 4neg contains 2 copies of Pfam domain PF00291 (Pyridoxal-phosphate dependent enzyme) in Tryptophan synthase beta chain. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036052
Domain description: Tryptophan synthase beta chain-like, PALP domain superfamily
Occurring in:
  1. Tryptophan synthase beta chain
IPR023026
Domain description: Tryptophan synthase beta chain/beta chain-like
Occurring in:
  1. Tryptophan synthase beta chain
IPR006654
Domain description: Tryptophan synthase, beta chain
Occurring in:
  1. Tryptophan synthase beta chain
IPR006653
Domain description: Tryptophan synthase, beta chain, conserved site
Occurring in:
  1. Tryptophan synthase beta chain
IPR001926
Domain description: Tryptophan synthase beta chain-like, PALP domain
Occurring in:
  1. Tryptophan synthase beta chain

Structure domain

CATH CATH domain
3.40.50.1100
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Tryptophan synthase beta chain
The deposited structure of PDB entry 4neg contains 4 copies of CATH domain 3.40.50.1100 (Rossmann fold) in Tryptophan synthase beta chain. Showing 2 copies in chain A.

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