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CFTR Associated Ligand (CAL) PDZ domain bound to peptide iCAL36(BRB-K-1) (ANSRWPTS[4-bromobenzoic-acyl-K]I)

X-ray diffraction
1.4Å resolution
PDB entry 4nmv coloured by chain, front view.
PDB entry 4nmv coloured by chain, side view.
PDB entry 4nmv coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Golgi-associated PDZ and coiled-coil motif-containing protein and peptide
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Multimeric state: hetero dimer
Accessible surface area: 5241.16 Å2
Buried surface area: 1148.44 Å2
Dissociation area: 470.39 Å2
Dissociation energy (ΔGdiss): 3 kcal/mol
Dissociation entropy (TΔSdiss): 6.96 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-164910
Assembly 2
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Assembly Name: Golgi-associated PDZ and coiled-coil motif-containing protein and peptide
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Multimeric state: hetero dimer
Accessible surface area: 5293.94 Å2
Buried surface area: 1319.92 Å2
Dissociation area: 572.64 Å2
Dissociation energy (ΔGdiss): 0.51 kcal/mol
Dissociation entropy (TΔSdiss): 7.59 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-164910

Macromolecules

Golgi-associated PDZ and coiled-coil motif-containing protein
Chains: A, B
Length: 87 amino acids
Theoretical weight: 9.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9HD26 (Residues: 284-370; Coverage: 19%)
Gene names: CAL, FIG, GOPC
Pfam: PDZ domain
InterPro:
CATH: Pdz3 Domain
Golgi-associated PDZ and coiled-coil motif-containing protein in PDB entry 4nmv, assembly 1, front view.
Golgi-associated PDZ and coiled-coil motif-containing protein in PDB entry 4nmv, assembly 1, side view.
Golgi-associated PDZ and coiled-coil motif-containing protein in PDB entry 4nmv, assembly 1, top view.
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iCAL36(BRB-K-1) peptide
Chains: C, D
Length: 10 amino acids
Theoretical weight: 1.34 KDa
Source organism: Homo sapiens
Expression system: Not provided
iCAL36(BRB-K-1) peptide in PDB entry 4nmv, assembly 1, front view.
iCAL36(BRB-K-1) peptide in PDB entry 4nmv, assembly 1, side view.
iCAL36(BRB-K-1) peptide in PDB entry 4nmv, assembly 1, top view.
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