› 4nwc

X-ray diffraction
2.01Å resolution

Crystal structure of the GluK3 ligand-binding domain (S1S2) in complex with the agonist (2S,4R)-4-(3-Methoxy-3-oxopropyl)glutamic acid at 2.01 A resolution.

Released:
DOI: 10.2210/pdb4nwc/pdb
PDB entry 4nwc coloured by chain, front view.
PDB entry 4nwc coloured by chain, side view.
PDB entry 4nwc coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Molecular recognition of two 2,4-syn-functionalized (S)-glutamate analogues by the kainate receptor GluK3 ligand binding domain.
Venskutonytė R, Larsen AP, Frydenvang K, Gajhede M, Sagot E, Assaf Z, Gefflaut T, Pickering DS, Bunch L, Kastrup JS
ChemMedChem 9 2254-9 (2014)
PMID: 25044437

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-154591 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, kainate 3 Chain: A
Molecule details ›
Chain: A
Length: 258 amino acids
Theoretical weight: 29.09 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P42264 (Residues: 432-546, 669-806; Coverage: 29%)
Gene names: Glur7, Grik3
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

4 bound ligands:
Ligand K 2 x K
Ligand PO4 1 x PO4
Ligand CL 1 x CL
Ligand 2QE 1 x 2QE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-3
Spacegroup: P4122
Unit cell:
a: 67.81Å b: 67.81Å c: 126.77Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.169 0.166 0.214
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.
Hansen et al. (2021)
2 other articles