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Crystal structure of the GluK3 ligand-binding domain (S1S2) in complex with the agonist (2S,4R)-4-(3-Methoxy-3-oxopropyl)glutamic acid at 2.01 A resolution.

X-ray diffraction
2.012Å resolution
PDB entry 4nwc coloured by chain, front view.
PDB entry 4nwc coloured by chain, side view.
PDB entry 4nwc coloured by chain, top view.
Source organism: Rattus norvegicus
Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Glutamate receptor ionotropic, kainate 3
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Multimeric state: monomeric
Accessible surface area: 12642.51 Å2
Buried surface area: 652.67 Å2
Dissociation area: 98.36 Å2
Dissociation energy (ΔGdiss): -0.33 kcal/mol
Dissociation entropy (TΔSdiss): 0.08 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-154591
Assembly 2
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Assembly Name: Glutamate receptor ionotropic, kainate 3
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Multimeric state: homo dimer
Accessible surface area: 23498.72 Å2
Buried surface area: 3093.7 Å2
Dissociation area: 896.08 Å2
Dissociation energy (ΔGdiss): 9.07 kcal/mol
Dissociation entropy (TΔSdiss): 13.22 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-154592

Macromolecules

Glutamate receptor ionotropic, kainate 3
Chain: A
Length: 258 amino acids
Theoretical weight: 29.09 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P42264 (Residues: 432-546, 669-806; Coverage: 29%)
Gene names: Glur7, Grik3
Pfam:
InterPro:
CATH: Periplasmic binding protein-like II
Glutamate receptor ionotropic, kainate 3 in PDB entry 4nwc, assembly 1, front view.
Glutamate receptor ionotropic, kainate 3 in PDB entry 4nwc, assembly 1, side view.
Glutamate receptor ionotropic, kainate 3 in PDB entry 4nwc, assembly 1, top view.
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