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Crystal Structure of the Q103N-MauG/pre-Methylamine Dehydrogenase Complex

Source organism: Paracoccus denitrificans PD1222
Biochemical function: methylamine dehydrogenase (amicyanin) activity
Biological process: methylamine metabolic process
Cellular component: periplasmic space

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EC 1.4.9.1: Methylamine dehydrogenase (amicyanin)

Reaction catalysed:
Methylamine + H(2)O + 2 oxidized [amicyanin] = formaldehyde + NH(3) + 2 reduced [amicyanin]
Systematic name:
Methylamine:amicyanin oxidoreductase (deaminating)
Alternative Name(s):
  • Amine dehydrogenase
  • Amine:(acceptor) oxidoreductase (deaminating)
  • MADH
  • Methylamine dehydrogenase
  • Primary-amine dehydrogenase
  • Primary-amine:(acceptor) oxidoreductase (deaminating)

GO terms

Sequence families

Pfam Protein families (Pfam)
PF06433
Domain description: Methylamine dehydrogenase heavy chain (MADH)
Occurring in:
  1. Methylamine dehydrogenase heavy chain
The deposited structure of PDB entry 4o1q contains 2 copies of Pfam domain PF06433 (Methylamine dehydrogenase heavy chain (MADH)) in Methylamine dehydrogenase heavy chain. Showing 1 copy in chain D.

PF02975
Domain description: Methylamine dehydrogenase, L chain
Occurring in:
  1. Methylamine dehydrogenase (amicyanin)
The deposited structure of PDB entry 4o1q contains 2 copies of Pfam domain PF02975 (Methylamine dehydrogenase, L chain) in Methylamine dehydrogenase (amicyanin). Showing 1 copy in chain C.

PF03150
Domain description: Di-haem cytochrome c peroxidase
Occurring in:
  1. Methylamine utilization protein MauG
The deposited structure of PDB entry 4o1q contains 2 copies of Pfam domain PF03150 (Di-haem cytochrome c peroxidase) in Methylamine utilization protein MauG. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR036909
Domain description: Cytochrome c-like domain superfamily
Occurring in:
  1. Methylamine utilization protein MauG
IPR036560
Domain description: Methylamine/Aralkylamine dehydrogenase light chain superfamily
Occurring in:
  1. Methylamine dehydrogenase (amicyanin)
IPR009451
Domain description: Amine dehydrogenase heavy chain
Occurring in:
  1. Methylamine dehydrogenase heavy chain
IPR013476
Domain description: Methylamine dehydrogenase heavy chain
Occurring in:
  1. Methylamine dehydrogenase heavy chain
IPR011044
Domain description: Quinoprotein amine dehydrogenase, beta chain-like
Occurring in:
  1. Methylamine dehydrogenase heavy chain
IPR015943
Domain description: WD40/YVTN repeat-like-containing domain superfamily
Occurring in:
  1. Methylamine dehydrogenase heavy chain
IPR013504
Domain description: Methylamine/Aralkylamine dehydrogenase light chain, C-terminal domain
Occurring in:
  1. Methylamine dehydrogenase (amicyanin)
IPR004229
Domain description: Methylamine dehydrogenase light chain
Occurring in:
  1. Methylamine dehydrogenase (amicyanin)
IPR016008
Domain description: Amine dehydrogenase light chain
Occurring in:
  1. Methylamine dehydrogenase (amicyanin)
IPR009056
Domain description: Cytochrome c-like domain
Occurring in:
  1. Methylamine utilization protein MauG
IPR004852
Domain description: Di-haem cytochrome c peroxidase
Occurring in:
  1. Methylamine utilization protein MauG

Structure domains

CATH CATH domains
1.10.760.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Cytochrome Bc1 Complex; Chain D, domain 2
Homology: Cytochrome c-like domain
Occurring in:
  1. Methylamine utilization protein MauG
The deposited structure of PDB entry 4o1q contains 4 copies of CATH domain 1.10.760.10 (Cytochrome Bc1 Complex; Chain D, domain 2) in Methylamine utilization protein MauG. Showing 2 copies in chain B.
2.130.10.10
Class: Mainly Beta
Architecture: 7 Propeller
Topology: Methylamine Dehydrogenase; Chain H
Homology: YVTN repeat-like/Quinoprotein amine dehydrogenase
Occurring in:
  1. Methylamine dehydrogenase heavy chain
The deposited structure of PDB entry 4o1q contains 2 copies of CATH domain 2.130.10.10 (Methylamine Dehydrogenase; Chain H) in Methylamine dehydrogenase heavy chain. Showing 1 copy in chain D.
2.60.30.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Electron Transport Ethylamine Dehydrogenase
Homology: Methylamine/Aralkylamine dehydrogenase light chain
Occurring in:
  1. Methylamine dehydrogenase (amicyanin)
The deposited structure of PDB entry 4o1q contains 2 copies of CATH domain 2.60.30.10 (Electron Transport Ethylamine Dehydrogenase) in Methylamine dehydrogenase (amicyanin). Showing 1 copy in chain C.

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