EC 2.7.7.86: Cyclic GMP-AMP synthase
Reaction catalysed:
(1a) ATP + GTP = pppG-P(2'-5')A + diphosphate
Systematic name:
ATP:GTP adenylyltransferase (cyclizing)
Alternative Name(s):
- CGAMP synthase
- CGAS
GO terms
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Sequence families
Protein families (Pfam)
InterPro annotations
Structure domains
CATH domains
1.10.1410.40
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Poly(a)-polymerase, middle domain
Homology:
Poly(a)-polymerase, middle domain
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>4o67</span> contains 2 copies of CATH domain <span class='highlight'>1.10.1410.40 (Poly(a)-polymerase, middle domain)</span> in <span class='highlight'>Cyclic GMP-AMP synthase</span>. Showing 1 copy in chain <span class='highlight'>B</span>. The deposited structure of PDB entry 4o67 contains 2 copies of CATH domain 1.10.1410.40 (Poly(a)-polymerase, middle domain) in Cyclic GMP-AMP synthase. Showing 1 copy in chain B.](https://www.ebi.ac.uk/pdbe/static/entry/4o67_1_B_CATH_1.10.1410.40_image-200x200.png)