› › Structure analysis

Zinc-free Rpn11 in complex with Rpn8

X-ray diffraction
1.95Å resolution
PDB entry 4o8y coloured by chain, front view.
PDB entry 4o8y coloured by chain, side view.
PDB entry 4o8y coloured by chain, top view.
Source organism: Saccharomyces cerevisiae S288C
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Proteasome complex
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Multimeric state: hetero dimer
Accessible surface area: 16164.86 Å2
Buried surface area: 8541.59 Å2
Dissociation area: 2,731.9 Å2
Dissociation energy (ΔGdiss): 11.49 kcal/mol
Dissociation entropy (TΔSdiss): 12.64 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155094

Macromolecules

26S proteasome regulatory subunit RPN8
Chain: A
Length: 185 amino acids
Theoretical weight: 21.04 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Escherichia coli
UniProt:
  • Canonical: Q08723 (Residues: 2-178; Coverage: 52%)
Gene names: O5360, RPN8, YOR261C
Pfam: JAB1/Mov34/MPN/PAD-1 ubiquitin protease
InterPro:
CATH: Cytidine Deaminase, domain 2
26S proteasome regulatory subunit RPN8 in PDB entry 4o8y, assembly 1, front view.
26S proteasome regulatory subunit RPN8 in PDB entry 4o8y, assembly 1, side view.
26S proteasome regulatory subunit RPN8 in PDB entry 4o8y, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q08723  
118520406080100120140160180
 
50100150MGSLQHEKVTIAPLVLLSALDHYERTQTKENKRCVGVILGDANSSTIRVTNSFALPFEEDEKNSDVWFLDHNYIENMNEMCKKINAKEKLIGWYHSGPKLRASDLKINELFKKYTQNNPLLLIVDVKQQGVGLPTDAYVAIEQVKDDGTSTEKTFLHLPCTIEAEEAEEIGVEHLLRDVLEVLFQ
UniProt
Q08723
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
Interaction interfaces
Sequence conservation
Molecule details ›

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Ubiquitin carboxyl-terminal hydrolase RPN11
Chain: B
Length: 240 amino acids
Theoretical weight: 26.89 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Escherichia coli
UniProt:
  • Canonical: P43588 (Residues: 2-239; Coverage: 78%)
Gene names: MPR1, RPN11, YFR004W
Pfam: JAB1/Mov34/MPN/PAD-1 ubiquitin protease
InterPro:
CATH: Cytidine Deaminase, domain 2
Ubiquitin carboxyl-terminal hydrolase RPN11 in PDB entry 4o8y, assembly 1, front view.
Ubiquitin carboxyl-terminal hydrolase RPN11 in PDB entry 4o8y, assembly 1, side view.
Ubiquitin carboxyl-terminal hydrolase RPN11 in PDB entry 4o8y, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P43588  
124020406080100120140160180200220240
 
100200
UniProt
P43588
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
Interaction interfaces
Sequence conservation
Molecule details ›

Search similar proteins

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