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Mechanism of transhydrogenase coupling proton translocation and hydride transfer

X-ray diffraction
6.926Å resolution
PDB entry 4o9u coloured by chain, front view.
PDB entry 4o9u coloured by chain, side view.
PDB entry 4o9u coloured by chain, top view.
Source organism: Thermus thermophilus HB27
Assembly composition:
hetero hexamer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: proton-translocating NAD(P)(+) transhydrogenase and NAD(P) transhydrogenase subunit beta
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Multimeric state: hetero hexamer
Accessible surface area: 68091.41 Å2
Buried surface area: 30849.43 Å2
Dissociation area: 2,282.62 Å2
Dissociation energy (ΔGdiss): 19.69 kcal/mol
Dissociation entropy (TΔSdiss): 15.63 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-180813

Macromolecules

proton-translocating NAD(P)(+) transhydrogenase
Chains: A, C
Length: 100 amino acids
Theoretical weight: 10.65 KDa
Source organism: Thermus thermophilus HB27
Expression system: Escherichia coli
UniProt:
  • Canonical: Q72GR9 (Residues: 1-100; Coverage: 100%)
Gene name: TT_C1779
Pfam: 4TM region of pyridine nucleotide transhydrogenase, mitoch
InterPro: NAD(P) transhydrogenase, alpha subunit, C-terminal
proton-translocating NAD(P)(+) transhydrogenase in PDB entry 4o9u, assembly 1, front view.
proton-translocating NAD(P)(+) transhydrogenase in PDB entry 4o9u, assembly 1, side view.
proton-translocating NAD(P)(+) transhydrogenase in PDB entry 4o9u, assembly 1, top view.
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NAD(P) transhydrogenase subunit beta
Chains: B, D
Length: 450 amino acids
Theoretical weight: 47.37 KDa
Source organism: Thermus thermophilus HB27
Expression system: Escherichia coli
UniProt:
  • Canonical: Q72GS0 (Residues: 1-450; Coverage: 100%)
Gene name: TT_C1778
Pfam: NAD(P) transhydrogenase beta subunit
InterPro:
NAD(P) transhydrogenase subunit beta in PDB entry 4o9u, assembly 1, front view.
NAD(P) transhydrogenase subunit beta in PDB entry 4o9u, assembly 1, side view.
NAD(P) transhydrogenase subunit beta in PDB entry 4o9u, assembly 1, top view.
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proton-translocating NAD(P)(+) transhydrogenase
Chains: E, F
Length: 384 amino acids
Theoretical weight: 41.26 KDa
Source organism: Thermus thermophilus HB27
Expression system: Escherichia coli
UniProt:
  • Canonical: Q72GR8 (Residues: 1-375; Coverage: 100%)
Gene name: TT_C1780
Pfam:
InterPro:
proton-translocating NAD(P)(+) transhydrogenase in PDB entry 4o9u, assembly 1, front view.
proton-translocating NAD(P)(+) transhydrogenase in PDB entry 4o9u, assembly 1, side view.
proton-translocating NAD(P)(+) transhydrogenase in PDB entry 4o9u, assembly 1, top view.
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