› › Structure analysis

Carbamate kinase from Giardia lamblia thiocarbamoylated by disulfiram on Cys242

X-ray diffraction
2.6Å resolution
PDB entry 4olc coloured by chain, front view.
PDB entry 4olc coloured by chain, side view.
PDB entry 4olc coloured by chain, top view.
Source organism: Giardia lamblia ATCC 50803
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Carbamate kinase
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Multimeric state: homo dimer
Accessible surface area: 23513.56 Å2
Buried surface area: 5574.45 Å2
Dissociation area: 2,162.81 Å2
Dissociation energy (ΔGdiss): 32.68 kcal/mol
Dissociation entropy (TΔSdiss): 13.82 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-108579
Assembly 2 (preferred)
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Assembly Name: Carbamate kinase
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Multimeric state: homo dimer
Accessible surface area: 24089.03 Å2
Buried surface area: 5384.51 Å2
Dissociation area: 2,222.18 Å2
Dissociation energy (ΔGdiss): 31.92 kcal/mol
Dissociation entropy (TΔSdiss): 13.87 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-108579

Macromolecules

Carbamate kinase
Chains: A, B, C, D
Length: 317 amino acids
Theoretical weight: 33.98 KDa
Source organism: Giardia lamblia ATCC 50803
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A8BB85 (Residues: 1-316; Coverage: 100%)
Gene name: GL50803_0016453
Pfam: Amino acid kinase family
InterPro:
CATH: Acetylglutamate kinase-like
Carbamate kinase in PDB entry 4olc, assembly 2, front view.
Carbamate kinase in PDB entry 4olc, assembly 2, side view.
Carbamate kinase in PDB entry 4olc, assembly 2, top view.
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