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Crystal Structure of the N-terminal Domain of Human Profilaggrin at 2.2 A Resolution

X-ray diffraction
2.2Å resolution
PDB entry 4pcw coloured by chain, front view.
PDB entry 4pcw coloured by chain, side view.
PDB entry 4pcw coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Filaggrin
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Multimeric state: homo dimer
Accessible surface area: 10449.57 Å2
Buried surface area: 3860.29 Å2
Dissociation area: 1,394.02 Å2
Dissociation energy (ΔGdiss): 20.95 kcal/mol
Dissociation entropy (TΔSdiss): 11.26 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-149090
Assembly 2
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Assembly Name: Filaggrin
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Multimeric state: homo dimer
Accessible surface area: 10744.55 Å2
Buried surface area: 4206.77 Å2
Dissociation area: 1,522.05 Å2
Dissociation energy (ΔGdiss): 21.63 kcal/mol
Dissociation entropy (TΔSdiss): 11.41 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-149090

Macromolecules

Filaggrin
Chains: A, B, C, D
Length: 94 amino acids
Theoretical weight: 11.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P20930 (Residues: 1-92; Coverage: 2%)
Gene name: FLG
Pfam: S-100/ICaBP type calcium binding domain
InterPro:
CATH: EF-hand
Filaggrin in PDB entry 4pcw, assembly 1, front view.
Filaggrin in PDB entry 4pcw, assembly 1, side view.
Filaggrin in PDB entry 4pcw, assembly 1, top view.
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