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Crystal Structure of PDE10A with 1H-benzimidazol-2-yl(4-((3-(tetrahydro-2H-pyran-4-yl)-2-pyridinyl)oxy)phenyl)methanone

X-ray diffraction
2.5Å resolution
PDB entry 4phw coloured by chain, front view.
PDB entry 4phw coloured by chain, side view.
PDB entry 4phw coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
homo dimer (preferred)
homo hexamer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
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Multimeric state: homo dimer
Accessible surface area: 27368.11 Å2
Buried surface area: 2726.32 Å2
Dissociation area: 637.4 Å2
Dissociation energy (ΔGdiss): 2.69 kcal/mol
Dissociation entropy (TΔSdiss): 13.44 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-195089
Homo dimeric assembly 1 of PDB entry 4phw coloured by chemically distinct molecules, front view.
Homo dimeric assembly 1 of PDB entry 4phw coloured by chemically distinct molecules, side view.
Homo dimeric assembly 1 of PDB entry 4phw coloured by chemically distinct molecules, top view.
    Assembly 1
Confidence : 48%
No. subunits : 2
Symmetry : C2
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3DComplex & QSbio predictionx
No. subunits : Unclear
Symmetry : Unclear
Evidence : This biological assembly agrees with none of the predictions of PISA & EPPIC
Assembly 2
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Assembly Name: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
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Multimeric state: homo hexamer
Accessible surface area: 80895.87 Å2
Buried surface area: 9428.21 Å2
Dissociation area: 2,191.51 Å2
Dissociation energy (ΔGdiss): 8.44 kcal/mol
Dissociation entropy (TΔSdiss): 43.5 kcal/mol
Symmetry number: 6
PDBe Complex ID: PDB-CPX-195091
Homo hexameric assembly 2 of PDB entry 4phw coloured by chemically distinct molecules, front view.
Homo hexameric assembly 2 of PDB entry 4phw coloured by chemically distinct molecules, side view.
Homo hexameric assembly 2 of PDB entry 4phw coloured by chemically distinct molecules, top view.
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Macromolecules

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Chains: A, B
Length: 351 amino acids
Theoretical weight: 40.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y233 (Residues: 718-1055; Coverage: 32%)
Gene name: PDE10A
InterPro:
CATH: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A in PDB entry 4phw, assembly 1, front view.
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A in PDB entry 4phw, assembly 1, side view.
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A in PDB entry 4phw, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q9Y233  
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