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PDE7A catalytic domain in complex with 2-(Cyclopentylamino)thieno[3,2-d]pyrimidin-4(3H)-one derivative

X-ray diffraction
2.1Å resolution
PDB entry 4pm0 coloured by chain, front view.
PDB entry 4pm0 coloured by chain, side view.
PDB entry 4pm0 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: High affinity 3',5'-cyclic-AMP phosphodiesterase 7A
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Multimeric state: monomeric
Accessible surface area: 14373.11 Å2
Buried surface area: 238.05 Å2
Dissociation area: 73.82 Å2
Dissociation energy (ΔGdiss): 17.24 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-171839

Macromolecules

High affinity 3',5'-cyclic-AMP phosphodiesterase 7A
Chain: A
Length: 389 amino acids
Theoretical weight: 44.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13946 (Residues: 130-482; Coverage: 73%)
Gene name: PDE7A
Pfam: 3'5'-cyclic nucleotide phosphodiesterase
InterPro:
CATH: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A in PDB entry 4pm0, assembly 1, front view.
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A in PDB entry 4pm0, assembly 1, side view.
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A in PDB entry 4pm0, assembly 1, top view.
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