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Human GKRP bound to AMG-3295 and Sorbitol-6-phosphate

X-ray diffraction
2.43Å resolution
PDB entry 4px3 coloured by chain, front view.
PDB entry 4px3 coloured by chain, side view.
PDB entry 4px3 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Glucokinase regulatory protein
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Multimeric state: monomeric
Accessible surface area: 22219.39 Å2
Buried surface area: 2685.58 Å2
Dissociation area: 76.2 Å2
Dissociation energy (ΔGdiss): -1.46 kcal/mol
Dissociation entropy (TΔSdiss): 1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-556426
Assembly 2 (preferred)
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Assembly Name: Glucokinase regulatory protein
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Multimeric state: monomeric
Accessible surface area: 22733.32 Å2
Buried surface area: 4075.61 Å2
Dissociation area: 85.42 Å2
Dissociation energy (ΔGdiss): -1.39 kcal/mol
Dissociation entropy (TΔSdiss): 1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-556426

Macromolecules

Glucokinase regulatory protein
Chains: A, B
Length: 638 amino acids
Theoretical weight: 70.31 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q14397 (Residues: 1-625; Coverage: 100%)
Gene name: GCKR
Pfam:
InterPro:
CATH: Glucose-6-phosphate isomerase like protein; domain 1
Glucokinase regulatory protein in PDB entry 4px3, assembly 2, front view.
Glucokinase regulatory protein in PDB entry 4px3, assembly 2, side view.
Glucokinase regulatory protein in PDB entry 4px3, assembly 2, top view.
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