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Human Aldose Reductase complexed with a ligand with an IDD structure ({5-fluoro-2-[(3-nitrobenzyl)carbamoyl]phenoxy}acetic acid) at 0.98 A

X-ray diffraction
0.98Å resolution
PDB entry 4qbx coloured by chain, front view.
PDB entry 4qbx coloured by chain, side view.
PDB entry 4qbx coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Aldo-keto reductase family 1 member B1
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Multimeric state: monomeric
Accessible surface area: 12702.28 Å2
Buried surface area: 1502.76 Å2
Dissociation area: 148.94 Å2
Dissociation energy (ΔGdiss): -0.73 kcal/mol
Dissociation entropy (TΔSdiss): 2.75 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-147224

Macromolecules

Aldo-keto reductase family 1 member B1
Chain: A
Length: 316 amino acids
Theoretical weight: 35.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P15121 (Residues: 1-316; Coverage: 100%)
Gene names: AKR1B1, ALDR1, ALR2
Pfam: Aldo/keto reductase family
InterPro:
CATH: NADP-dependent oxidoreductase domain
Aldo-keto reductase family 1 member B1 in PDB entry 4qbx, assembly 1, front view.
Aldo-keto reductase family 1 member B1 in PDB entry 4qbx, assembly 1, side view.
Aldo-keto reductase family 1 member B1 in PDB entry 4qbx, assembly 1, top view.
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