Structure analysis

Crystal structure of the tetrameric dGTP/dCTP-bound SAMHD1 (RN206) mutant catalytic core

X-ray diffraction
2.1Å resolution
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo tetramer
Accessible surface area: 68742.48 Å2
Buried surface area: 29558.93 Å2
Dissociation area: 5,827.98 Å2
Dissociation energy (ΔGdiss): 34.4 kcal/mol
Dissociation entropy (TΔSdiss): 17.12 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-195223

Macromolecules

Chains: A, B, C, D
Length: 550 amino acids
Theoretical weight: 63.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y3Z3 (Residues: 113-626; Coverage: 82%)
Gene names: MOP5, SAMHD1
Pfam: HD domain
InterPro:
CATH: Hypothetical protein af1432

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