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co-crystal structure of MDM2 (17-111) with compound 16, {(3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-1-[(1S)-1-(6-CYCLOPROPYLPYRIDIN-2-YL)PROPYL]-3-METHYL-2-OXOPIPERIDIN-3-YL}ACETIC ACID

X-ray diffraction
1.7Å resolution
PDB entry 4qo4 coloured by chain, front view.
PDB entry 4qo4 coloured by chain, side view.
PDB entry 4qo4 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: E3 ubiquitin-protein ligase Mdm2
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Multimeric state: monomeric
Accessible surface area: 5513.03 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169499

Macromolecules

E3 ubiquitin-protein ligase Mdm2
Chain: A
Length: 96 amino acids
Theoretical weight: 11.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q00987 (Residues: 17-111; Coverage: 19%)
Gene name: MDM2
Pfam: SWIB/MDM2 domain
InterPro:
CATH: SWIB/MDM2 domain
E3 ubiquitin-protein ligase Mdm2 in PDB entry 4qo4, assembly 1, front view.
E3 ubiquitin-protein ligase Mdm2 in PDB entry 4qo4, assembly 1, side view.
E3 ubiquitin-protein ligase Mdm2 in PDB entry 4qo4, assembly 1, top view.
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