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Crystal Structure of ERKs in complex with 5-chlorobenzo[d]oxazol-2-amine

X-ray diffraction
2.23Å resolution
PDB entry 4qp2 coloured by chain, front view.
PDB entry 4qp2 coloured by chain, side view.
PDB entry 4qp2 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Mitogen-activated protein kinase 1
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-151230
Assembly 2
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Assembly Name: Mitogen-activated protein kinase 1
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-151230

Macromolecules

Mitogen-activated protein kinase 1
Chains: A, B
Length: 369 amino acids
Theoretical weight: 42.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P28482 (Residues: 1-360; Coverage: 100%)
Gene names: ERK2, MAPK1, PRKM1, PRKM2
Pfam: Protein kinase domain
InterPro:
CATH:
Mitogen-activated protein kinase 1 in PDB entry 4qp2, assembly 1, front view.
Mitogen-activated protein kinase 1 in PDB entry 4qp2, assembly 1, side view.
Mitogen-activated protein kinase 1 in PDB entry 4qp2, assembly 1, top view.
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