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Crystal structure of hSTING(S162A/G230I/Q266I) in complex with DMXAA

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: positive regulation of type I interferon production
Cellular component: not assigned

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GO terms

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF15009
Domain description: Transmembrane protein 173
Occurring in:
  1. Stimulator of interferon genes protein
The deposited structure of PDB entry 4qxr contains 2 copies of Pfam domain PF15009 (Transmembrane protein 173) in Stimulator of interferon genes protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR029158
Domain description: Stimulator of interferon genes protein
Occurring in:
  1. Stimulator of interferon genes protein
IPR038623
Domain description: Stimulator of interferon genes protein, C-terminal domain superfamily
Occurring in:
  1. Stimulator of interferon genes protein
IPR047191
Domain description: Stimulator of interferon genes protein, C-terminal
Occurring in:
  1. Stimulator of interferon genes protein
IPR033952
Domain description: Stimulator of interferon genes protein homolog, C-terminal
Occurring in:
  1. Stimulator of interferon genes protein

Structure domains

CATH CATH domains
3.40.50.12100
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Stimulator of interferon genes protein
Occurring in:
  1. Stimulator of interferon genes protein
The deposited structure of PDB entry 4qxr contains 2 copies of CATH domain 3.40.50.12100 (Rossmann fold) in Stimulator of interferon genes protein. Showing 1 copy in chain A.
1.20.5.5200
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Occurring in:
  1. Stimulator of interferon genes protein
The deposited structure of PDB entry 4qxr contains 2 copies of CATH domain 1.20.5.5200 (Single alpha-helices involved in coiled-coils or other helix-helix interfaces) in Stimulator of interferon genes protein. Showing 1 copy in chain A.

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