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Crystal structure of hSTING(S162A/G230I/Q266I) in complex with DMXAA

X-ray diffraction
2.37Å resolution
PDB entry 4qxr coloured by chain, front view.
PDB entry 4qxr coloured by chain, side view.
PDB entry 4qxr coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: STING complex
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Multimeric state: homo dimer
Accessible surface area: 17052.29 Å2
Buried surface area: 3687.63 Å2
Dissociation area: 1,773.94 Å2
Dissociation energy (ΔGdiss): 5.88 kcal/mol
Dissociation entropy (TΔSdiss): 12.8 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-183240
Complex Portal ID: CPX-2127

Macromolecules

Stimulator of interferon genes protein
Chains: A, B
Length: 188 amino acids
Theoretical weight: 21.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86WV6 (Residues: 155-341; Coverage: 49%)
Gene names: ERIS, MITA, STING, STING1, TMEM173
Pfam: Transmembrane protein 173
InterPro:
CATH:
Stimulator of interferon genes protein in PDB entry 4qxr, assembly 1, front view.
Stimulator of interferon genes protein in PDB entry 4qxr, assembly 1, side view.
Stimulator of interferon genes protein in PDB entry 4qxr, assembly 1, top view.
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