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Crystal structure of yeast aminopeptidase 1 (Ape1)

X-ray diffraction
2.5Å resolution
PDB entry 4r8f coloured by chain, front view.
PDB entry 4r8f coloured by chain, side view.
PDB entry 4r8f coloured by chain, top view.
Source organism: Saccharomyces cerevisiae S288C
Assembly composition:
homo dodecamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Vacuolar aminopeptidase 1
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Multimeric state: homo dodecamer
Accessible surface area: 160176.22 Å2
Buried surface area: 71039.03 Å2
Dissociation area: 21,409.22 Å2
Dissociation energy (ΔGdiss): 172.79 kcal/mol
Dissociation entropy (TΔSdiss): 84.84 kcal/mol
Symmetry number: 12
PDBe Complex ID: PDB-CPX-147137

Macromolecules

Vacuolar aminopeptidase 1
Chains: A, B, C, D
Length: 470 amino acids
Theoretical weight: 51.89 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P14904 (Residues: 46-514; Coverage: 91%)
Gene names: APE1, API, LAP4, YKL103C, YKL455, YSC1
Pfam: Aminopeptidase I zinc metalloprotease (M18)
InterPro:
CATH:
Vacuolar aminopeptidase 1 in PDB entry 4r8f, assembly 1, front view.
Vacuolar aminopeptidase 1 in PDB entry 4r8f, assembly 1, side view.
Vacuolar aminopeptidase 1 in PDB entry 4r8f, assembly 1, top view.
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