Structure analysis

EGFR kinase (T790M/L858R) with inhibitor compound 4

X-ray diffraction
2.7Å resolution
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 15144.89 Å2
Buried surface area: 185.49 Å2
Dissociation area: 92.75 Å2
Dissociation energy (ΔGdiss): 14.85 kcal/mol
Dissociation entropy (TΔSdiss): 0.6 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-132671

Macromolecules

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