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Crystal structure of S39D HDAC8 in complex with a largazole analogue.

X-ray diffraction
2.18Å resolution
PDB entry 4rn1 coloured by chain, front view.
PDB entry 4rn1 coloured by chain, side view.
PDB entry 4rn1 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Histone deacetylase 8
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Multimeric state: monomeric
Accessible surface area: 14919.39 Å2
Buried surface area: 666.21 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-189815
Assembly 2
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Assembly Name: Histone deacetylase 8
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Multimeric state: monomeric
Accessible surface area: 14438.98 Å2
Buried surface area: 227.05 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-189815

Macromolecules

Histone deacetylase 8
Chains: A, B
Length: 389 amino acids
Theoretical weight: 43.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9BY41 (Residues: 1-377; Coverage: 100%)
Gene names: CDA07, HDAC8, HDACL1
Pfam: Histone deacetylase domain
InterPro:
CATH: Histone deacetylase domain
Histone deacetylase 8 in PDB entry 4rn1, assembly 1, front view.
Histone deacetylase 8 in PDB entry 4rn1, assembly 1, side view.
Histone deacetylase 8 in PDB entry 4rn1, assembly 1, top view.
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