› › Structure analysis

Crystal structure of human farnesyl diphosphate synthase in complex with BPH-1358

X-ray diffraction
2.2Å resolution
PDB entry 4rxa coloured by chain, front view.
PDB entry 4rxa coloured by chain, side view.
PDB entry 4rxa coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Farnesyl pyrophosphate synthase
hide full assembly name
Multimeric state: homo dimer
Accessible surface area: 28954.85 Å2
Buried surface area: 4462.93 Å2
Dissociation area: 1,987.48 Å2
Dissociation energy (ΔGdiss): 20.06 kcal/mol
Dissociation entropy (TΔSdiss): 14.13 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-146902

Macromolecules

Farnesyl pyrophosphate synthase
Chain: A
Length: 348 amino acids
Theoretical weight: 40.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P14324 (Residues: 72-419; Coverage: 83%)
Gene names: FDPS, FPS, KIAA1293
Pfam: Polyprenyl synthetase
InterPro:
CATH: Farnesyl Diphosphate Synthase
Farnesyl pyrophosphate synthase in PDB entry 4rxa, assembly 1, front view.
Farnesyl pyrophosphate synthase in PDB entry 4rxa, assembly 1, side view.
Farnesyl pyrophosphate synthase in PDB entry 4rxa, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links