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Crystal structure of the mutant I26A/N52A of the endoribonuclease from human coronavirus 229E

X-ray diffraction
2.504Å resolution
PDB entry 4s1t coloured by chain, front view.
PDB entry 4s1t coloured by chain, side view.
PDB entry 4s1t coloured by chain, top view.
Source organism: Human coronavirus 229E
Assembly composition:
homo hexamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Viral protein genome-linked nsp9
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Multimeric state: homo hexamer
Accessible surface area: 81132.38 Å2
Buried surface area: 20194.89 Å2
Dissociation area: 2,147.98 Å2
Dissociation energy (ΔGdiss): 10.14 kcal/mol
Dissociation entropy (TΔSdiss): 16.02 kcal/mol
Symmetry number: 6
PDBe Complex ID: PDB-CPX-143097
Assembly 2
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Assembly Name: Viral protein genome-linked nsp9
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Multimeric state: homo hexamer
Accessible surface area: 81092.79 Å2
Buried surface area: 20263.82 Å2
Dissociation area: 2,027.66 Å2
Dissociation energy (ΔGdiss): 8.48 kcal/mol
Dissociation entropy (TΔSdiss): 15.99 kcal/mol
Symmetry number: 6
PDBe Complex ID: PDB-CPX-143097

Macromolecules

Uridylate-specific endoribonuclease
Chains: A, B, C, D, E, F
Length: 349 amino acids
Theoretical weight: 38.82 KDa
Source organism: Human coronavirus 229E
Expression system: Escherichia coli
UniProt:
  • Canonical: P0C6X1 (Residues: 6111-6458; Coverage: 5%)
Gene names: 1a-1b, rep
Pfam:
InterPro:
CATH:
Uridylate-specific endoribonuclease in PDB entry 4s1t, assembly 1, front view.
Uridylate-specific endoribonuclease in PDB entry 4s1t, assembly 1, side view.
Uridylate-specific endoribonuclease in PDB entry 4s1t, assembly 1, top view.
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