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Crystal Structure of Human Transthyretin Ala108Trp Mutant

X-ray diffraction
1.75Å resolution
PDB entry 4tlu coloured by chain, front view.
PDB entry 4tlu coloured by chain, side view.
PDB entry 4tlu coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Transthyretin
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Multimeric state: homo tetramer
Accessible surface area: 19024.75 Å2
Buried surface area: 6630.93 Å2
Dissociation area: 1,500.95 Å2
Dissociation energy (ΔGdiss): 18.81 kcal/mol
Dissociation entropy (TΔSdiss): 12.76 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-136168

Macromolecules

Transthyretin
Chains: A, B
Length: 125 amino acids
Theoretical weight: 14.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P02766 (Residues: 29-147; Coverage: 94%)
Gene names: PALB, TTR
Pfam: HIUase/Transthyretin family
InterPro:
CATH: Transthyretin/hydroxyisourate hydrolase domain
Transthyretin in PDB entry 4tlu, assembly 1, front view.
Transthyretin in PDB entry 4tlu, assembly 1, side view.
Transthyretin in PDB entry 4tlu, assembly 1, top view.
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