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Crystal Structure of G Protein-Coupled Receptor Kinase 5 in Complex with AMP-PNP

X-ray diffraction
1.802Å resolution
PDB entry 4tnd coloured by chain, front view.
PDB entry 4tnd coloured by chain, side view.
PDB entry 4tnd coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: G protein-coupled receptor kinase 5
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Multimeric state: monomeric
Accessible surface area: 25635.04 Å2
Buried surface area: 967.44 Å2
Dissociation area: 442.85 Å2
Dissociation energy (ΔGdiss): 1.75 kcal/mol
Dissociation entropy (TΔSdiss): 5.37 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-152756

Macromolecules

G protein-coupled receptor kinase 5
Chain: A
Length: 590 amino acids
Theoretical weight: 67.94 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P34947 (Residues: 1-590; Coverage: 100%)
Gene names: GPRK5, GRK5
Pfam:
InterPro:
CATH:
G protein-coupled receptor kinase 5 in PDB entry 4tnd, assembly 1, front view.
G protein-coupled receptor kinase 5 in PDB entry 4tnd, assembly 1, side view.
G protein-coupled receptor kinase 5 in PDB entry 4tnd, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P34947  
159050100150200250300350400450500550
 
200400
UniProt
P34947
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