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Human EphA3 Kinase domain in complex with compound 164

X-ray diffraction
2.047Å resolution
PDB entry 4two coloured by chain, front view.
PDB entry 4two coloured by chain, side view.
PDB entry 4two coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Ephrin type-A receptor 3
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Multimeric state: monomeric
Accessible surface area: 13204.68 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-151400

Macromolecules

Ephrin type-A receptor 3
Chain: A
Length: 361 amino acids
Theoretical weight: 40.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P29320 (Residues: 609-947; Coverage: 35%)
Gene names: EPHA3, ETK, ETK1, HEK, TYRO4
Pfam:
InterPro:
CATH:
Ephrin type-A receptor 3 in PDB entry 4two, assembly 1, front view.
Ephrin type-A receptor 3 in PDB entry 4two, assembly 1, side view.
Ephrin type-A receptor 3 in PDB entry 4two, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P29320  
136150100150200250300350
 
100200300
UniProt
P29320
Chains
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Secondary structure
Flexibility predictions
Topology annotations
Early folding residue predictions
Ligand binding sites
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