› 4u2r

X-ray diffraction
1.41Å resolution

Crystal structure of the GLUR2 ligand binding core (S1S2J, flip variant) in the apo state

Released:
DOI: 10.2210/pdb4u2r/pdb
PDB entry 4u2r coloured by chain, front view.
PDB entry 4u2r coloured by chain, side view.
PDB entry 4u2r coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structure and dynamics of AMPA receptor GluA2 in resting, pre-open, and desensitized states.
Dürr KL, Chen L, Stein RA, De Zorzi R, Folea IM, Walz T, Mchaourab HS, Gouaux E
Cell 158 778-792 (2014)
PMID: 25109876

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo tetramer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148604 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 263 amino acids
Theoretical weight: 29.19 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P19491 (Residues: 413-527, 653-796; Coverage: 30%)
  • Best match: P19491-2 (Residues: 413-527, 653-796)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P212121
Unit cell:
a: 66.659Å b: 91.936Å c: 201.344Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.212 0.232
Expression system: Escherichia coli

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Citations

32 review citations

The Lysosome as a Regulatory Hub.
Perera et al. (2016)
31 more