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Crystal structure of the GLUR2 ligand binding core (S1S2J, flip variant) in the apo state

X-ray diffraction
1.411Å resolution
PDB entry 4u2r coloured by chain, front view.
PDB entry 4u2r coloured by chain, side view.
PDB entry 4u2r coloured by chain, top view.
Source organism: Rattus norvegicus
Assemblies composition:
homo tetramer
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Glutamate receptor 2
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Multimeric state: homo tetramer
Accessible surface area: 49811.86 Å2
Buried surface area: 5307.45 Å2
Dissociation area: 2,428.44 Å2
Dissociation energy (ΔGdiss): -10.67 kcal/mol
Dissociation entropy (TΔSdiss): 40.6 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-148611
Assembly 2 (preferred)
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Assembly Name: Glutamate receptor 2
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Multimeric state: monomeric
Accessible surface area: 13794.52 Å2
Buried surface area: 223.66 Å2
Dissociation area: 111.83 Å2
Dissociation energy (ΔGdiss): 17.02 kcal/mol
Dissociation entropy (TΔSdiss): 0.6 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148604
Assembly 3
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Assembly Name: Glutamate receptor 2
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Multimeric state: monomeric
Accessible surface area: 13657.42 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148604
Assembly 4
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Assembly Name: Glutamate receptor 2
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Multimeric state: monomeric
Accessible surface area: 13587.24 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148604
Assembly 5
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Assembly Name: Glutamate receptor 2
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Multimeric state: monomeric
Accessible surface area: 13629.58 Å2
Buried surface area: 226.9 Å2
Dissociation area: 113.45 Å2
Dissociation energy (ΔGdiss): 16.51 kcal/mol
Dissociation entropy (TΔSdiss): 0.6 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148604

Macromolecules

Glutamate receptor 2
Chains: A, B, C, D
Length: 263 amino acids
Theoretical weight: 29.19 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P19491 (Residues: 413-527, 653-796; Coverage: 30%)
  • Best match: P19491-2 (Residues: 413-527, 653-796)
Gene names: GluA2, Glur2, Gria2
Pfam:
InterPro:
CATH: Periplasmic binding protein-like II
Glutamate receptor 2 in PDB entry 4u2r, assembly 2, front view.
Glutamate receptor 2 in PDB entry 4u2r, assembly 2, side view.
Glutamate receptor 2 in PDB entry 4u2r, assembly 2, top view.
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