› › Structure analysis

HIV-1 wild Type protease with GRL-050-10A (a Gem-difluoro-bis-Tetrahydrofuran as P2-Ligand)

X-ray diffraction
1.3Å resolution
PDB entry 4u8w coloured by chain, front view.
PDB entry 4u8w coloured by chain, side view.
PDB entry 4u8w coloured by chain, top view.
Source organism: Human immunodeficiency virus type 1 BH10
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Protease
hide full assembly name
Multimeric state: homo dimer
Accessible surface area: 9346.91 Å2
Buried surface area: 4810.64 Å2
Dissociation area: 1,989.73 Å2
Dissociation energy (ΔGdiss): 26.23 kcal/mol
Dissociation entropy (TΔSdiss): 11.44 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-136848

Macromolecules

Protease
Chains: A, B
Length: 99 amino acids
Theoretical weight: 10.74 KDa
Source organism: Human immunodeficiency virus type 1 BH10
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P03366 (Residues: 501-599; Coverage: 7%)
Gene name: gag-pol
Pfam: Retroviral aspartyl protease
InterPro:
CATH: Acid Proteases
Protease in PDB entry 4u8w, assembly 1, front view.
Protease in PDB entry 4u8w, assembly 1, side view.
Protease in PDB entry 4u8w, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links