Assemblies
Assembly Name:
alpha-thrombin complex and Hirudin variant-2
Multimeric state:
hetero trimer
Accessible surface area:
12773.99 Å2
Buried surface area:
4048.55 Å2
Dissociation area:
593.86
Å2
Dissociation energy (ΔGdiss):
0.6
kcal/mol
Dissociation entropy (TΔSdiss):
7.63
kcal/mol
Symmetry number:
1
PDBe Complex ID:
PDB-CPX-133076
Macromolecules
Chain: H
Length: 258 amino acids
Theoretical weight: 29.65 KDa
Source organism: Homo sapiens
UniProt:
Pfam: Trypsin
InterPro:
Length: 258 amino acids
Theoretical weight: 29.65 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P00734 (Residues: 364-621; Coverage: 43%)
Pfam: Trypsin
InterPro:
- Serine proteases, trypsin domain
- Peptidase S1, PA clan
- Peptidase S1, PA clan, chymotrypsin-like fold
- Peptidase S1A, chymotrypsin family
- Serine proteases, trypsin family, histidine active site
- Prothrombin/thrombin
- Serine proteases, trypsin family, serine active site
Chain: I
Length: 12 amino acids
Theoretical weight: 1.55 KDa
Source organism: Hirudo medicinalis
Expression system: Not provided
UniProt:
Length: 12 amino acids
Theoretical weight: 1.55 KDa
Source organism: Hirudo medicinalis
Expression system: Not provided
UniProt:
- Canonical: P09945 (Residues: 61-72; Coverage: 19%)
Chain: L
Length: 29 amino acids
Theoretical weight: 3.43 KDa
Source organism: Homo sapiens
UniProt:
Pfam: Thrombin light chain
InterPro:
Length: 29 amino acids
Theoretical weight: 3.43 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P00734 (Residues: 333-361; Coverage: 5%)
Pfam: Thrombin light chain
InterPro:
