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4ug2 › Structure analysis

Thermostabilised HUMAN A2a Receptor with CGS21680 bound

X-ray diffraction

2.6Å resolution

PDB entry 4ug2 coloured by chain, front view.

PDB entry 4ug2 coloured by chain, side view.

PDB entry 4ug2 coloured by chain, top view.

Source organism: Homo sapiens

Assembly composition:

monomeric (preferred)

Entry contents: 1 distinct polypeptide molecule

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4ug2 overview
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Assembly composition XML
Assembly 1 (mmCIF; gz)
Assembly 2 (mmCIF; gz)
Assembly 1 (atom only; mmCIF)
Assembly 2 (atom only; mmCIF)
Archive mmCIF file
Updated mmCIF file
PDB file
PDB header
PDB file (gz)
PDBML
PDBML (ATOM lines)
PDBML (no atoms)
Structure Factors
EDS map
EDS difference map
FASTA (Entry)

Assemblies

Assembly 1 (preferred)

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Assembly Name: Adenosine receptor A2a
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Multimeric state: monomeric

Accessible surface area: 14351.98 Å²

Buried surface area: 0.0 Å²

Dissociation area: 0 Å²

Dissociation energy (ΔG^diss): 0 kcal/mol

Dissociation entropy (TΔS^diss): 0 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-151373

Monomeric assembly 1 of PDB entry 4ug2 coloured by chemically distinct molecules, front view.

Monomeric assembly 1 of PDB entry 4ug2 coloured by chemically distinct molecules, side view.

Monomeric assembly 1 of PDB entry 4ug2 coloured by chemically distinct molecules, top view.

Monomeric assembly 1 of PDB entry 4ug2 coloured by chemically distinct molecules, front view.

Monomeric assembly 1 of PDB entry 4ug2 coloured by chemically distinct molecules, side view.

Monomeric assembly 1 of PDB entry 4ug2 coloured by chemically distinct molecules, top view.

Assembly 2

Download 3D Visualisation

Assembly Name: Adenosine receptor A2a
hide full assembly name

Multimeric state: monomeric

Accessible surface area: 13593.29 Å²

Buried surface area: 0.0 Å²

Dissociation area: 0 Å²

Dissociation energy (ΔG^diss): 0 kcal/mol

Dissociation entropy (TΔS^diss): 0 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-151373

Monomeric assembly 2 of PDB entry 4ug2 coloured by chemically distinct molecules, front view.

Monomeric assembly 2 of PDB entry 4ug2 coloured by chemically distinct molecules, side view.

Monomeric assembly 2 of PDB entry 4ug2 coloured by chemically distinct molecules, top view.

Monomeric assembly 2 of PDB entry 4ug2 coloured by chemically distinct molecules, front view.

Monomeric assembly 2 of PDB entry 4ug2 coloured by chemically distinct molecules, side view.

Monomeric assembly 2 of PDB entry 4ug2 coloured by chemically distinct molecules, top view.

Macromolecules

Adenosine receptor A2a

Chains: A, B
Length: 325 amino acids
Theoretical weight: 36.02 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:

Canonical: P29274 (Residues: 1-317; Coverage: 77%)

Gene names: ADORA2, ADORA2A
Pfam: 7 transmembrane receptor (rhodopsin family)
InterPro:

Adenosine receptor
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
Adenosine A2A receptor

CATH: Rhodopsin 7-helix transmembrane proteins

Adenosine receptor A2a in PDB entry 4ug2, assembly 1, front view.

Adenosine receptor A2a in PDB entry 4ug2, assembly 1, side view.

Adenosine receptor A2a in PDB entry 4ug2, assembly 1, top view.

FASTA Sequence


    >pdb|4ug2|A B

MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSAAAADILVGVLAIPFAIAISTGFCAACHGCLFIACFVLVLTASSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKAHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAAAENLYFQ

PDBe-KB: UniProt Coverage View: P29274

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UniProt

P29274

Mapping to UniProt AA2AR_HUMAN

Chains

RSRZ Outlier Chain A

Chain A

RSRZ Outlier Chain B

Chain B

Domains

Residues mapped to CATH domains

Residues mapped to InterPro annotations

Secondary structure

Residues forming Helix

Residues forming Strand

Flexibility predictions

Flexibility predictions

Flexibility predictions

Early folding residue predictions

Early folding residue predictions

Ligand binding sites

Residues binding 2-[P-(2-CARBOXYETHYL)PHENYLETHYL-AMINO]-5'-N-ETHYLCARBOXAMIDO ADENOSINE <br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/NGI_200.svg" /><span>

Residues binding (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate <br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/OLB_200.svg" /><span>

Sequence conservation

Amino acid probabilities The amino acid probabilities are calculated using HMM profiles based on multiple sequence alignments. Click to see more details...

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Amino acid properties

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Proline

Positive charge

Cysteine

Glycine

Variants

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Molecule details ›

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FASTA (Protein chains A, B)
Archive mmCIF file
Updated mmCIF file
PDB file
PDB header
PDB file (gz)
PDBML
PDBML (ATOM lines)
PDBML (no atoms)
Structure Factors
SIFTS XML file with residue-level mappings

Search similar proteins

Similar 3D structures (PDBeFold)
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BLAST P29274 (UniProt)

Quick links

4ug2 overview
- Citations
Structure analysis
Function and Biology
Ligands and Environments
Experiments and Validation

Downloads

Close

Assembly composition XML
Assembly 1 (mmCIF; gz)
Assembly 2 (mmCIF; gz)
Assembly 1 (atom only; mmCIF)
Assembly 2 (atom only; mmCIF)
Archive mmCIF file
Updated mmCIF file
PDB file
PDB header
PDB file (gz)
PDBML
PDBML (ATOM lines)
PDBML (no atoms)
Structure Factors
EDS map
EDS difference map
FASTA (Entry)

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