Structure analysis

The cryoEM structure of human gamma-Secretase complex

Electron Microscopy
4.4Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero pentamer (preferred)
Entry contents: 5 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentamer
Accessible surface area: 52908.48 Å2
Buried surface area: 37.63 Å2
Dissociation area: 18.81 Å2
Dissociation energy (ΔGdiss): -25.3 kcal/mol
Dissociation entropy (TΔSdiss): 25.54 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-112954

Macromolecules

Chain: A
Length: 588 amino acids
Theoretical weight: 63.33 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
158850100150200250300350400450500550
 
200400IPLNKTAPCVRLLNATHQIGCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAGLAVSLTKPSPASGFSPSVQCPNDGFGVYHCREIQWNSLGNGLAYEDFSFPIFLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIAAVCDPLSDYNVWSMLKPIADDVVVAATRLDSRSFAWNVAPGAESAVASFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVDSFVELGQVALRTSLELWMHTDPVQKNESVRNQVEDLGAGVPAVILRSGVPLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLAPEEDLNFVTDTAKALADVATVLGRALYELAGGDTVQADPQTVTRLLYGFLIKLRQDLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVV**************************************TARLARALSPAQWSSTEYSTWTESRWKAIRARIFLIAS***********************
UniProt
Q92542
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Sequence conservation
Variants

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Chain: B
Length: 241 amino acids
Theoretical weight: 23.55 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
124120406080100120140160180200220240
 
100200************HVIMLFVPVTLCMVVVVATI***************************LLLFFFSFIYLGEVFKTY**********LIWNFG*************RLQQAYLIMISALM********************D********************D******************WNTTIACFVAILIGLCLTLL*****************GLVFYFATDYLVQPFADQLAFH**
UniProt
P49768
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Sequence conservation

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Chain: C
Length: 196 amino acids
Theoretical weight: 16.7 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
119620406080100120140160180
 
50100150****************************************************************************************************************************************************************************************************
Chains
Chain C (auth C)
Secondary structure
Flexibility predictions
Early folding residue predictions

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Chain: D
Length: 62 amino acids
Theoretical weight: 5.29 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
16251015202530354045505560
 
204060**************************************************************
Chains
Chain D (auth D)
Secondary structure
Flexibility predictions
Early folding residue predictions
Sequence conservation

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Chain: G
Length: 162 amino acids
Theoretical weight: 18.44 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
116220406080100120140160
 
50100150MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYK
UniProt
D9IEF7
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Sequence conservation

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