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N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 7-(3,4-dimethoxyphenyl)-N-(1,1-dioxo-1-thian-4-yl)-5-methyl-4-oxo-4H,5H-thieno-3,2-c-pyridine-2- carboxamide

X-ray diffraction
1.58Å resolution
PDB entry 4uix coloured by chain, front view.
PDB entry 4uix coloured by chain, side view.
PDB entry 4uix coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Bromodomain-containing protein 4
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Multimeric state: monomeric
Accessible surface area: 7532.09 Å2
Buried surface area: 327.65 Å2
Dissociation area: 132.21 Å2
Dissociation energy (ΔGdiss): 3.19 kcal/mol
Dissociation entropy (TΔSdiss): -0.28 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-130112
Assembly 2
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Assembly Name: Bromodomain-containing protein 4
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Multimeric state: monomeric
Accessible surface area: 7585.37 Å2
Buried surface area: 333.87 Å2
Dissociation area: 134.46 Å2
Dissociation energy (ΔGdiss): 3.24 kcal/mol
Dissociation entropy (TΔSdiss): -0.28 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-130112
Assembly 3
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Assembly Name: Bromodomain-containing protein 4
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Multimeric state: monomeric
Accessible surface area: 6987.75 Å2
Buried surface area: 193.08 Å2
Dissociation area: 96.54 Å2
Dissociation energy (ΔGdiss): -0.07 kcal/mol
Dissociation entropy (TΔSdiss): -0.26 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-130112

Macromolecules

Bromodomain-containing protein 4
Chains: A, B, C
Length: 127 amino acids
Theoretical weight: 15.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60885 (Residues: 44-168; Coverage: 9%)
Gene names: BRD4, HUNK1
Pfam: Bromodomain
InterPro:
CATH: Bromodomain-like
Bromodomain-containing protein 4 in PDB entry 4uix, assembly 1, front view.
Bromodomain-containing protein 4 in PDB entry 4uix, assembly 1, side view.
Bromodomain-containing protein 4 in PDB entry 4uix, assembly 1, top view.
PDBe-KB: UniProt Coverage View: O60885  
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