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N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 7-(3,4-dimethoxyphenyl)-2-(4-methanesulfonylpiperazine-1-carbonyl)-5-methyl-4H,5H-thieno-3,2-c- pyridin-4-one

X-ray diffraction
1.19Å resolution
PDB entry 4uiz coloured by chain, front view.
PDB entry 4uiz coloured by chain, side view.
PDB entry 4uiz coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Bromodomain-containing protein 4
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Multimeric state: monomeric
Accessible surface area: 7888.01 Å2
Buried surface area: 277.12 Å2
Dissociation area: 99.84 Å2
Dissociation energy (ΔGdiss): -0.24 kcal/mol
Dissociation entropy (TΔSdiss): -0.27 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-130112

Macromolecules

Bromodomain-containing protein 4
Chain: A
Length: 127 amino acids
Theoretical weight: 15.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60885 (Residues: 44-168; Coverage: 9%)
Gene names: BRD4, HUNK1
Pfam: Bromodomain
InterPro:
CATH: Bromodomain-like
Bromodomain-containing protein 4 in PDB entry 4uiz, assembly 1, front view.
Bromodomain-containing protein 4 in PDB entry 4uiz, assembly 1, side view.
Bromodomain-containing protein 4 in PDB entry 4uiz, assembly 1, top view.
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