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Crystal structure of human Rab11-Rabin8-FIP3

X-ray diffraction
2.604Å resolution
PDB entry 4uj5 coloured by chain, front view.
PDB entry 4uj5 coloured by chain, side view.
PDB entry 4uj5 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Rab-3A-interacting protein and Ras-related protein Rab-11A
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Multimeric state: hetero dimer
Accessible surface area: 17511.04 Å2
Buried surface area: 2527.59 Å2
Dissociation area: 663.8 Å2
Dissociation energy (ΔGdiss): -2.13 kcal/mol
Dissociation entropy (TΔSdiss): 11.82 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158625
Assembly 2
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Assembly Name: Rab-3A-interacting protein and Ras-related protein Rab-11A
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Multimeric state: hetero dimer
Accessible surface area: 16854.61 Å2
Buried surface area: 2252.0 Å2
Dissociation area: 634.38 Å2
Dissociation energy (ΔGdiss): -3.2 kcal/mol
Dissociation entropy (TΔSdiss): 11.71 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158625

Macromolecules

Ras-related protein Rab-11A
Chains: A, B
Length: 185 amino acids
Theoretical weight: 20.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P62491 (Residues: 6-186; Coverage: 84%)
Gene names: RAB11, RAB11A
Pfam: Ras family
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
Ras-related protein Rab-11A in PDB entry 4uj5, assembly 1, front view.
Ras-related protein Rab-11A in PDB entry 4uj5, assembly 1, side view.
Ras-related protein Rab-11A in PDB entry 4uj5, assembly 1, top view.
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Rab-3A-interacting protein
Chains: C, D
Length: 195 amino acids
Theoretical weight: 22.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96QF0 (Residues: 286-476; Coverage: 40%)
Gene names: RAB3IP, RABIN8
InterPro: Guanine nucleotide exchange factor RAB3IL/RAB3IP/Sec2
Rab-3A-interacting protein in PDB entry 4uj5, assembly 1, front view.
Rab-3A-interacting protein in PDB entry 4uj5, assembly 1, side view.
Rab-3A-interacting protein in PDB entry 4uj5, assembly 1, top view.
Molecule details ›

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